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Androgen receptor modulating carboxamides for the treatment of cancer
专利权人:
ORION CORPORATION
发明人:
TÖRMÄKANGAS OLLI,WOHLFAHRT GERD,SALO HARRI,RAMASUBRAMANIAN RATHNA DURGA,PATRA PRANAB KUMAR,MARTIN ARPUTHARAJ EBENEZER,HEIKKINEN TERHI,VESALAINEN ANNIINA,MOILANEN ANU,KARJALAINEN ARJA
申请号:
NZ61639512
公开号:
NZ616395A
申请日:
2012.04.20
申请国别(地区):
NZ
年份:
2015
代理人:
摘要:
Provided are cyano-phenyl-pyrazole carboxamide derivative compounds of the general formula (I) or the general formula (II), wherein the variables are as defined in the specification. Examples of the compounds include (S)-N-(1-(3-(3-Chloro-4-cyano-2,5-difluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-methyl-1H-imidazole-5-carboxamide and (S)-N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(2-hydroxy-2-methylpropyl)-1H-pyrazole-3-carboxamide. The compounds are androgen receptor (AR) antagonists. The compounds may be useful in the treatment of prostate cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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