David Middlemiss,Edward Andrew Boyd,Eric Roy Pettipher,Frederick Arthur Brookfield,Mark Richard Ashton
申请号：
BRPI0415374
公开号：
BRPI0415374B1
申请日:
2004.10.19
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
"use of a compound, compound, process for preparing it, pharmaceutical composition, process for preparing it, and, product". compound of the general formula (i) wherein r 1, 4, r 2, r 3 and r 4 are independently hydrogen, halo, C 1-6 alkyl, -o (C 1-6 alkyl), 1 ~ -c ~ 6 ~), -con (r ^ 11 ^) ~ 2 ~, -sor ^ 11 ^, -so ~ 2 ~ r ^ 11 ^, -so ~ 2 ~ n (r ^ 11 ^) ~ 2 ~, -n (r ^ 11 ^) ~ 2 ~, nr ^ 11 ^ color ^ 11 ^, -co ~ 2 ~ r ^ 11 ^, -color ^ 11 ^, -sr ^ 11 ^, -oh, - no is ~ or ~ cn； each R 11 is independently hydrogen or C 1-6 alkyl； R 5 and R 6 are each independently hydrogen, or C 1-6 alkyl or together with the carbon atom to which they are attached form a C 3-7 cycloalkyl group ~； R7 is hydrogen or C1-6 alkyl； R 8 is an aromatic moiety optionally substituted by one or more substituents selected from halo, C 1-6 alkyl, C 1-6 alkyl, con (R 11) ~ 2 ~, -sor ^ 11 ^, -so ~ 2 ~ r ^ 11 ^, -so ~ 2 ~ n (r ^ 11 ^) ~ 2 ~, -n (r ^ 11 ^) ~ 2 ~, -nr ^ 11 ^ color ^ 11 ^, -co ~ 2 ~ r ^ 11 ^, -color ^ 11 ^, -sr ^ 11 ^, -oh, -no-2 ~ or -cn； wherein r 11 is as defined above； R 9 is hydrogen, or C 1-6 alkyl； provided that: R 8 is not phenyl substituted with -cooh； when any two of r ^ 1 ^, r ^ 2 ^, r ^ 3 ^ and r ^ 4 ^ are hydrogen, neither of the other two of r ^ 1 ^, r ^ 2 ^, r ^ 3 ^ and r ^ 4 ^ are alkyl c ~ 3 ~ c ~ 6 ~； and pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs thereof are useful in the preparation of pharmaceuticals for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis."uso de um composto, composto, processo para a preparação do mesmo, composição farmacêutica, processo para a preparação da mesma, e, produto". composto de fórmula geral (i) em que r^ 1^, r^ 2^, r^ 3^ e r^ 4^ são independentemente hidrogênio, halo, alquila c~ 1~-c~ 6~, -o(alquila c~ 1~-c~ 6~), -con(r^ 11^)~ 2~, -sor^ 11^, -so~ 2~r^ 11^, -so~ 2~n(r^ 11^)~ 2~, -n(r^ 11^)~ 2~, nr^ 11^cor^ 11^, -co~ 2~r^ 11^, -cor^ 11^, -sr^ 11^, -oh, -no~ 2~ ou -cn； cad
