OU, CHIEN CHIH,欧建志,歐建志,SU, MUH HWAN,苏慕寰,蘇慕寰,LIU, CHI LING,刘琪玲,劉琪玲
申请号：
TW104126409
公开号：
TW201609643A
申请日:
2015.08.13
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present application discloses a compound of formula (I), a polymorph, a tautomer, an enantiomer, a stereoisomer, a solvate, or a pharmaceutically acceptable salt thereof for blocking blood stream: wherein each of R1 - R6, independently, is R, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR, SO2R, SO3R, SO2NRR, SR, NRR, NRSO2NRR", NRSO2R, NRSO3R, NRC(O)R, NRC(O)NRR", NRC(O)OR, NRC(N)NRR", C(O)R, C(O)OR, C(O)NRR and wherein each of R, R, and R", independently, is hydrogen, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, cyclyl, or heterocyclyl.本案揭示用於阻斷血流的式(I)化合物,其多晶型,互變異構物、鏡像異構物、立體異構物、溶劑化物或醫藥上可接受的鹽:其中每個R1-R6,獨立地為R、硝基、亞硝基、氰基、疊氮化物、互變異構物、鏡像異構物、立體異構物、溶劑化物或醫藥上可接受的鹽、OR、OC(O)R、OC(O)OR、OC(O)NRR、SO2R、SO3R、SO2NRR、SR、NRR、NRSO2NRR"、NRSO2R、NRSO3R"、NRC(O)R、NRC(O)NRR"、NRC(O)OR、NRC(N)NRR"、C(O)R、C(O)OR、C(O)NRR;並且其中每個R、R和R"獨立地是氫、鹵素、烷基、烯基、炔基、環烷基、雜環烷基、環烯基、雜環烯基、芳基、雜芳基、環基或雜環基。
