DEHGHANI, Fariba,RAVARIAN, Roya,CHRZANOWSKI, Wojciech
申请号：
AUAU2014/000126
公开号：
WO2014/124496A1
申请日:
2014.02.14
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
According to the present invention there is provided a composite material comprising a covalently coupled polymer-bioglass, wherein the polymer is either functionalised with a coupling agent or includes a co-monomer coupling agent adapted to covalently couple the polymer and bioglass. The invention also relates to a method of production of a composite material comprising the steps of: preparing an inorganic sol of bioglass precursors； preparing an organic sol of polymer； combining the inorganic sol and said organic sol under such conditions to produce a covalently coupled polymer-bioglass composite material. The method further relates to forming a composite material in situ or in vivo, comprising the steps of delivering to a subject in need thereof a polymer sol and a bioglass sol to a predetermined location in the body of the subject and in situ catalysing the formation of a hybrid bioglass-polymer composite material. The method also relates to a formulation for preparing a composite material, and a kit comprising in separate containers: a bioglass sol, a copolymer sol and a catalyst. The invention further relates to the use of a hybrid composite as a bone filler, as an injectable formulation, or as a porous scaffold for biomedical purposes. A method for improving the long term stability of an implantable medical device is disclosed, and a method for regenerating or resurfacing tissue, comprising the step of: contacting said tissue with the hybrid composite of the invention.La présente invention concerne un matériau composite comprenant un polymère-bioverre couplé de façon covalente, le polymère étant fonctionnalisé avec un agent de couplage ou comprenant un agent de couplage de comonomère adapté pour coupler de façon covalente le polymère et le bioverre. L'invention concerne en outre un procédé de production d'un matériau composite comprenant les étapes de : préparation d'un sol inorganique de précurseurs de bioverre； préparation d'un sol organique de polymère； co
