MORENO OFIR,NATARAJAN SATEESH,DUNCAN DAVID F.,MORENO Ofir,NATARAJAN Sateesh,DUNCAN David F.
申请号：
SI200731377
公开号：
SI1986622T1
申请日:
2007.02.15
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
