WOODDELL, CHRISTINE I.,ROZEMA, DAVID B.,LEWIS, DAVID L.,WAKEFIELD, DARREN H.,ALMEIDA, LAUREN J
申请号：
CA2991639
公开号：
CA2991639A1
申请日:
2016.08.05
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Described are compositions and methods for inhibition of Hepatitis B virus gene expression. RNA interference (RN Ai) triggers and RNAi trigger conjugates for inhibiting the expression of Hepatitis B virus gene are described. Pharmaceutical compositions comprising one or more HBV RNAi triggers optionally with one or more additional therapeutics are also described. Delivery of the described HBV RNAi triggers to infected liver in vivo provides for inhibition of HBV gene expression and treatment.
