University College Dublin; Dublin; National University of Ireland
发明人:
Kinsella, B. Therese,Reid, Helen
申请号：
AU2016280058
公开号：
AU2016280058A1
申请日:
2016.06.13
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The invention relates to novel chemical entities that act as thromboxane (TX) A2 receptor, or T prostanoid receptor (TP), antagonists and to their use in the treatment of human diseases in which thromboxane (TX) A and of all other agents that act as incidental ligands of TP, including the endoperoxide prostaglandin (PG)G2/PGH2, 20-hydroxyeicosatetraenoic acid (20-HETE) and the free -radical derived isoprostanes (e.g., 8-iso-prostaglandin (PG)F2α)i play a role. Compounds of the invention preferably include a benzenesulfonyl urea in which the benzene is substituted by a substituted biphenylyloxy group (e.g., at the 2 position) and by a nitrile group (e.g., at the 5 position), which compounds show promising results as TP-isoform selective TP antagonists.
