Medical and Pharmaceutical Industry Technology and Development Center
发明人:
Shu-Wen Whu,Chung-Chih Cheng,Chih-Chiang Yang
申请号：
US14258860
公开号：
US20140314867A1
申请日:
2014.04.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A vitamin K2 microsphere. The microsphere includes a poly(lactide-co-glycolide) acid (PLGA) particle, in which the Mw of PLGA is between 1000 and 300000, and the molar ratio between the lactide repeat units and the glycolide repeate unit is 1-9:9-1； and one or more vitamin K2 molecules are embedded in the PLGA particle, wherein the vitamin K2 is present in an amount of 0.005-75 wt %, based on the weight of the microsphere. Also disclosed are a method of preparing the vitamin K2 microsphere, a method of treating osteoporosis using this microsphere, and a pharmaceutical composition containing the microsphere.
