PRÉPARATION CONTENANT UN ANTICORPS

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专利权人:

Chugai Seiyaku Kabushiki Kaisha

发明人:

SAEKI, Atsushi,NISHIZAWA, Shaw,SASAKI, Hitoshi,IMAI, Chifumi,IGAWA, Tomoyuki

申请号：

EP17789638

公开号：

EP3449940A4

申请日:

2017.04.27

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The present invention relates to stable antibody-containing solution formulations in which aggregate formation of Emicizumab (ACE910) which is a bispecific antibody functionally substituting for FVIII, is suppressed. Specifically, the present invention relates to the above-mentioned antibody-containing solution formulations of pH 4.5 to 6.5 that contain the aforementioned bispecific antibody at 20 to 180 mg/mL, 10 mM to 40 mM histidine-aspartate buffer, Poloxamer 188 at 0.2 to 1 mg/mL, and 100 mM to 300 mM arginine.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/