雙特異性T細胞活化抗原結合分子农业专利-农业学术服务平台

发明人:: KLEIN, CHRISTIAN,克雷恩　克里斯俊,BACAC, MARINA,贝卡克　玛莉娜,貝卡克　瑪莉娜,FREIMOSER-GRUNDSCHOBER, ANNE,富雷摩舍－葛伦雪伯　安,富雷摩捨－葛倫雪伯　安,HERTER, SYLVIA,赫特　希尔维雅,赫特　希爾維雅,ARRIBAS, JOAQUIN,爱瑞巴斯　乔钦,愛瑞巴斯　喬欽,VICARIO, ROCIO,维卡李,克雷恩克里斯俊,贝卡克玛莉娜,貝卡克瑪莉娜,富雷摩舍-葛伦雪伯安,富雷摩捨-葛倫雪伯安,赫特希尔维雅,赫特希爾維雅,爱瑞巴斯乔钦,愛瑞巴斯喬欽

摘要：: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.本發明概言之係關於用於T細胞活化及重新定向至特異性靶細胞之新穎雙特異性抗原結合分子。另外，本發明係關於編碼該等雙特異性抗原結合分子之多核苷酸及包含該等多核苷酸之載體及宿主細胞。本發明進一步係關於產生本發明之該等雙特異性抗原結合分子之方法，及使用該等雙特異性抗原結合分子治療疾病之方法。