雙特異性T細胞活化抗原結合分子农业专利-农业专业知识服务系统

发明人:: BACAC, MARINA,巴凯克　玛丽娜,巴凱克　瑪麗娜,FAUTI, TANJA,佛蒂　坦嘉,IMHOF-JUNG, SABINE,因霍夫－俊　沙宾,因霍夫－俊　沙賓,KLEIN, CHRISTIAN,克连　克利斯添,克連　克利斯添,KLOSTERMANN, STEFAN,克劳斯特曼　史蒂芬,克勞斯特曼　史蒂芬,MOESSNER, EKKEHARD,摩斯纳　艾克哈得,摩斯納　艾克哈,巴凯克玛丽娜,巴凱克瑪麗娜,佛蒂坦嘉,因霍夫-俊沙宾,因霍夫-俊沙賓,克连克利斯添,克連克利斯添,克劳斯特曼史蒂芬,克勞斯特曼史蒂芬,摩斯纳艾克哈得,摩斯納艾克哈

摘要：: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.本發明大體上係關於用於T細胞活化及使其再定向至特定靶細胞的新穎雙特異性抗原結合分子。另外，本發明係關於編碼此類雙特異性抗原結合分子的聚核苷酸，以及包含此類聚核苷酸的載體及宿主細胞。本發明進一步關於製造本發明之雙特異性抗原結合分子的方法，及使用此等雙特異性抗原結合分子治療疾病的方法。