BISMUTH-CONTAINING COMPOUNDS, COORDINATION POLYMERS, METHODS FOR MODULATING PHARMACOKINETIC PROPERTIES OF BIOLOGICALLY ACTIVE AGENTS, AND METHODS FOR TREATING PATIENTS
John D. Price;Thomas Piccariello;Scott B. Palmer;Michaela E. Mulhare;Robert A. Oberlender
发明人:
John D. Price,Thomas Piccariello,Robert A. Oberlender,Michaela E. Mulhare,Scott B. Palmer
申请号：
US12941599
公开号：
US20120115823A1
申请日:
2010.11.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Bismuth-containing compounds include bismuth and a biologically active agent coordinated to the bismuth. The biologically active agent includes at least one heteroatom configured for coordination with the bismuth. Coordination polymers include a polymer matrix that contains a bismuth-containing compound. Methods for modulating a pharmacokinetic property of a biologically active agent include coordinating the biologically active agent to bismuth to form a bismuth-containing compound, and administering the bismuth-containing compound orally to a patient. Methods for treating Parkinson's disease, methods for treating hypothyroidism, methods for treating ulcerative colitis, and methods for treating cancer each include administering a bismuth-containing compound to a patient.
