The invention provides a kind of composition, it includes following thyroid stimulating hormone receptor (TSHR) peptide：(i) amino acid sequence KKKKYVSIDVTLQQLESHKKK (SEQ ID NO:1) all or part, either one part or with SEQ ID NO:1 has the sequence of at least 60% sequence identity；(ii) amino acid sequence GLKMFPDLTKVYSTD (SEQ ID NO:2) all or part, either one part or with SEQ ID NO:2 have the sequence of at least 60% sequence identity.The invention further relates to purposes of the such composition in activation autoantibody in preventing or suppressing Graves disease is formed.
