The invention relates to active compound combinations, in particular a fungicidal and/or insecticidal composition, comprising Isotianil (3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide, CAS No 224049-04-1) and another insecticide flubendiamide (Cas No 272451-65-7) and optionally one further insecticide of the neonicotinoids.Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi and/or microorganisms and/or pests of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.本發明係有關活性化合物組合物,特別是殺真菌及/或殺昆蟲組成物,其含有異提尼(isotianil)(3,4-二氯-N-(2-氰苯基)-5-異噻唑甲醯胺,CAS No 224049-04-1)與另一殺昆蟲劑氟蟲醯胺(flubendiamide)(Cas No 272451-65-7)及視需要之一種進一步新類菸鹼類殺昆蟲劑。此外,本發明係有關治療性或預防性防治植物或作物之植物病原性真菌及/或微生物及/或病蟲害之方法、使用根據本發明之組合物處理種子之用途、保護種子而非只是處理種子之方法。