Delivery of telmisartan by making formulations containing nanocrystals or disordered crystals of it and a process without use of alkalanizers or solvents for the preparation thereof.
Nanocrystals and disordered nanocrystals of telmisartan were prepared by comilling telmisartan with poly (vinyl alcohol). These comilled "telmisartan-poly (vinyl alcohol)" products were fabricated into suitable solid dosage form. The type, size and the shape of the comilled telmisartan- poly (vinyl alcohol) bearing solid dosage forms designed to fit for the oral use. From the formulated dosage forms 75% or more of telmisartan incorporated as the dose was dissolved within 30 minutes, in water or an aqueous solution of pH 3 to 9. The formulation also posses required stability upon storage, for long periods of time.
