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STABILISATION DE FORMULATIONS AQUEUSES DE PROTEINES AVEC DES TAMPONS DE DEPLACEMENT
专利权人:
ARECOR LIMITED
发明人:
申请号:
EP08700170.7
公开号:
EP2114456B1
申请日:
2008.01.11
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
An aqueous composition having increased protein stability is obtained by: a. determining a pH at which the protein has stability at the desired temperature; b. adding to the composition at least one displacement buffer wherein the displacement buffer has a pKa that is at least 1 unit greater or less than the pH of step (a); and c. adjusting the pH of the composition to the pH of step (a); wherein the aqueous composition does not comprise a conventional buffer at a concentration greater than about 2 mM and wherein the conventional buffer has a pKa that is within 1 unit of the pH of step (a).
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