William ROSTENE,Christophe BAUDOUIN,David GODEFROY,Alexandre DENOYER
申请号：
US15235144
公开号：
US20160346406A1
申请日:
2016.08.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention concerns a method for inducing an increase in the intraocular pressure in an animal, said method comprising ocular administration of a solution comprising benzalkonium chloride (BAK). The present invention further relates to an animal having ocular hypertension, said animal being obtained by the method according to the invention. Said animal provides a convenient animal model for better understanding of the patho-physiological mechanisms involved in ocular hypertension and glaucoma. The present invention also relates to the use of said animal for screening a compound for therapeutic use against ocular hypertension or glaucoma, and/or for assessing potential side-effects of treatment of ocular hypertension and glaucoma.
