An antimicrobial oxychlorine oral rinse composition for preventing and treating oral malodor and diseases, tooth decay with improved palatability and tissue compatibility, includes an aqueous chlorine dioxide and chlorite ion solution with the chlorite ion predominating in the multiple oxychlorine rinse composition. A method for preparing such antimicrobial oxychlorine oral rinse composition comprising 3 ppm to about 200 ppm of chlorine dioxide, by first preparing an aqueous solution with about 7 to 400 ppm of chlorite ion； then an aqueous acidifying agent concentrate which, upon introduction to the chlorite solution, reduces its pH to about 4.5 to 6.0； then a second aqueous buffer-producing oxidant combination concentrate. The first acidifying agent concentrate is added to the chlorite ion solution and the second aqueous buffer-producing oxidant combination concentrate is added to the acidified chlorite ion solution, producing an antimicrobial oxychlorine oral rinse composition at about 5.0 to 6.8 pH.
