CELLULES SOUCHES MALIGNES INDUITES OU CELLULES SOUCHES CANCÉREUSES AVANT INDUCTION SUSCEPTIBLES D'AUTORÉPLICATION HORS D'UN ORGANISME, LEUR PROCÉDÉ D'OBTENTION ET LEURS APPLICATIONS PRATIQUES ASSOCIÉES
The present invention provides an induced cancer cell capable of self-replication in vitro which is useful in cancer therapy research and the research for cancer-related drug discovery, processes for production thereof, cancer cells induced by the malignant cells, and applications of these cells. The present invention provides an induced cancer stem cell capable of proliferation (self-replication) in vitro, wherein the induced cancer stem cell has the following two characteristics: (1) expressing the six genes (self-renewal related genes) POU5F1, NANOG, SOX2, ZFP42, LIN28, and TERT selected from a certain group of genes； and (2) having an aberration which is either (a) a mutation in an endogenous tumor suppressor gene or (b) increased expression of an endogenous cancer-related gene.
