Derivatives of N-(arylamino) sulfonamides including polymorphs as inhibitors of MEK as well as compositions, methods of use and methods for preparing the same
Vernier, Jean-michel,Miner, Jeffrey N.,Quart, Barry,Girardet, Jean-luc,Dimock, Stuart,Rowlings, Colin Edward
申请号：
AU2008282338
公开号：
AU2008282338B2
申请日:
2008.07.28
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
This invention concerns N-(2-arylamino) aryl sulfonamide compounds whichare inhibitors of MEK including crystalline polymorphic forms which exhibita specific powder x-ray diffraction profile and/or a specific differentialscanning calorimetry profile. This invention also concerns pharmaceuticalcompositions comprising the compounds described herein and methods of use ofthe compounds and compositions described herein, including the use in the treatmentand/or prevention of cancer, hyperproliferative diseases and inflammatoryconditions. The invention also concerns methods of making the compunds and compositionsdescribed herein.
