DERIVATIVES OF N-(ARYLAMINO) SULFONAMIDES INCLUDING POLYMORPHS AS INHIBITORS OF MEK AS WELL AS COMPOSITIONS, METHODS OF USE AND METHODS FOR PREPARING THE SAME
This invention concerns N-(2-arylamino) aryl sulfonamide compounds which are inhibitors of MEK including crystalline polymorphic forms which exhibit a specific powder x-ray diffraction profile and/or a specific differential scanning calorimetry profile. This invention also concerns pharmaceutical compositions comprising A compound disclosed hereinand methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer, hyperproliferative disorders and inflammatory conditions. The invention also concerns methods of making the compunds and compositions described herein.本發明係關於作為MEK抑制劑之N-(2-芳胺基)芳基磺醯胺化合物,其包括呈現特定粉末x光繞射曲線及/或特定示差掃描熱量測定曲線之結晶多晶型。本發明亦係關於包含本文揭露之化合物的醫藥組合物及使用本文揭露之化合物與組合物用於治療及/或預防癌症、過度增生性病症及發炎症狀之方法。本發明亦係關於製備本文揭露之化合物與組合物的方法。(無元件符號說明)
