Immobilization molecules and their applications of anti-stead2 antibodies, antibody drug conjugates, and bicarbonate antigens identified as stead2 and CD3
Generally speaking, six kinds of prostate membrane 2 (stap2) proteins called adrenal antigens are very strong in prostate cancer, which are related to the expression of other genes related to prostate cancer. The current invention provides antibodies to full-length human IgGS refers to human stap2 (monomer antibody). The present invention also provides new double antibodies (bsabs), which are identified as stap2 and CD3, and activate T lymphocytes through the CD3 complex in the case of stap2 tumor. B. In some waysThe present invention provides two kinds of antigen curing molecules, including the first antigen curing characteristic specially for human and monkey CD3, and the second antigen curing molecule specially for human stap2. In some implementations,At present, the solidifying molecules of two antigens may inhibit the growth of tumor expressed by stap2. The solidifying molecules of the two antigens invented are helpful for the treatment of prostate diseases and disorders, in which the immune response to stat2 induced or managed by the host is desirable and / or beneficial. For example, the two antibodies are useful in the treatment of prostate cancer,The invention also includes an anti castrated prostate cancer and an anti adiabatic antibody conjugate that inhibits the growth of a living tumor.RESUMEN La proteína conocida como antígeno epitelial de seis transmembranas de próstata 2 (STEAP2) se expresa altamente en el cáncer de próstata y está asociada con la expresión de otros genes asociados con el cáncer de próstata. La presente invención proporciona anticuerpos contra IgG humana de longitud completa novedosos que se fijan a STEAP2 humano (anticuerpos monoespecíficos). La presente invención también proporciona anticuerpos biespecíficos (bsAbs) novedosos que se fijan a STEAP2 y CD3 y activan los linfocitos T a través del complejo CD3 en presencia de tumores que expresan STEAP2. De acuerdo con determinadas formas de realización, la presente invención proporcion
