ГРИН Джеймс Тринка (US),УИЛКИСОН Уилльям Оуэн (US)
申请号：
RU2013105481/15
公开号：
RU2013105481A
申请日:
2011.07.07
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A pharmaceutical composition comprising: (1) an immediate release solid phase which contains: (a) remogliflosin etabonate or a salt thereof； and (b) an immediate release material, and (2) a sustained release solid phase that contains: (a) remogliflosin etabonate or a salt thereof； and a sustained release material where the sustained release solid phase is dispersed or enclosed in an immediate release solid phase, and where Cremoglyphlozin of etabonate or a salt thereof from a sustained release solid phase is achieved in plasma after reaching Cremoglyphlozin etabonate or its salt from an immediate release solid phase, upon administration of this pharmaceutical compositions to a mammal. 2. The pharmaceutical composition according to claim 1, which is used with the once-daily administration regimen, wherein the total content of remoglyphlozin etabonate or its salt contained in the solid phase of sustained release and in the solid phase of immediate release is from 5 mg to 500 mg. The pharmaceutical composition according to claim 1, wherein the sustained release solid phase is in the form of discrete individual particles or granules, and the immediate release solid phase is essentially a matrix that has individual particles of a sustained release solid phase enclosed in or dispersed in the matrix. four. The pharmaceutical composition according to claim 1, wherein the sustained release material present in the sustained release solid phase contains one or more hydrophilic polymers, or one or more hydrophobic polymers, or one or more other hydrophobic1. Фармацевтическая композиция, содержащая:(1) твердую фазу немедленного высвобождения, которая содержит: (a) ремоглифлозина этабонат или его соль； и (b) материал немедленного высвобождения, и(2) твердую фазу замедленного высвобождения, которая содержит: (a) ремоглифлозина этабонат или его соль； и материал замедленного высвобождения, гдетвердая фаза с замедленным высвобождением диспергирована или заключена в твердой фазе не
