extended release solid dosage forms abstract a solid oral dosage form includes a core comprising a non-ionic polymer matrix, a first amount of a first antiemetic drug or a pharmaceutically acceptable salt thereof dispersed within the matrix, and a salt dispersed within the matrix； a first seal coat of a non-ionic polymer matrix surrounding the core； and an immediate release drug layer surrounding the first seal coat, wherein the immediate release drug layer comprises a non-ionic polymer and a second amount of a second antiemetic drug or a pharmaceutically acceptable salt thereof dispersed therein, wherein the drug layer is sufficiently designed to release the second amount of the antiemetic drug over a period of at least 1 hour, wherein the solid oral dosage form is sufficiently designed to release the first amount of the first antiemetic drug and the second amount of the second antiemetic drug over a minimum period of 16 hours -------------------------------------------------- -------------------------------------------------- Patent Summary: "Extended release solid dosage forms of antiemetics". solid oral dosage form including a core comprising a nonionic polymer matrix, a first amount of a first antiemetic drug or a pharmaceutically acceptable salt thereof dispersed in the matrix, and a salt dispersed in the matrix； a first sealing coating of a nonionic polymer matrix surrounding the core； and an immediate release drug layer surrounding the first seal coating, wherein the immediate release drug layer comprises a nonionic polymer and a second amount of a second antiemetic drug or a pharmaceutically acceptable salt thereof dispersed therein, wherein the The drug layer is sufficiently designed to release the second amount of the antiemetic drug over a period of at least 1 hour, wherein the solid oral dosage form is sufficiently designed to release the first amount of the first antiemetic drug and the second amount of the antiemetic drug. second antiemetic drug for a
