A method, system and apparatus are described for decontaminating small enclosures, semi-enclosed and closed areas of pathogens by using a very dry mist comprising ionized hydrogen peroxide. The system can be controlled manually by the user, or by a remote connection, such as a wireless network connection. The method includes use of a handheld, point-and-spray device that sprays a very dry mist comprising ionized hydrogen peroxide under manual or automated control.