CHALMERS, DEREK T.,查尔摩斯 迪克T,查爾摩斯 迪克T,JONES, JAMES B.,琼斯 詹姆士B,瓊斯 詹姆士B
申请号：
TW103137239
公开号：
TW201601743A
申请日:
2014.10.28
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
A method for preventing, inhibiting or treating nausea and/or vomiting in a mammalian subject, the method comprising administering an effective amount of a peripherally-restricted kappa opioid receptor agonist to the subject. The nausea and/or vomiting can be associated with use of an opioid, such as morphine or fentanyl. The peripherally-restricted kappa opioid receptor agonist can be an L-amino acid-containing peptide, a D-amino acid-containing peptide, or a synthetic peptide amide, such as for instance, D-Phe-D-Phe-D-Leu-D-Lys-[ω(4-aminopiperidine-4-carboxylic acid)]-OH (CR845).一種預防、抑制或治療一哺乳動物個體之噁心及/或嘔吐的方法,該方法包含施予該個體一有效量的外周限制的κ鴉片受體促進劑。噁心及/或嘔吐可與一例如嗎啡(morphine)或吩坦尼(fentanyl)的鴉片類藥物的使用有關。該外周限制的κ鴉片受體促進劑可為一含有L型胺基酸之胜肽、一含有D型胺基酸之胜肽、或是一合成的胜肽胺基化合物,例如D-Phe-D-Phe-D-Leu-D-Lys-[ω(4-氨基哌啶-4-羧酸)]-OH(CR845)。
