The present disclosure provides new biodegradable amphiphilic peptides and peptide analogs based on poly (L-lysineisophthalamide) (PLP) derivatives containing hydrophobic chains, and permeabilization of mammalian cells, And their use in the delivery of drugs such as therapeutic agents, contrast agents, and cell preservatives. [Selection] Figure 9B本開示は、疎水性鎖を含むポリ(L-リジンイソフタルアミド)(PLP)誘導体に基づく新たな生分解性両親媒性である、ペプチド及びペプチド類似体の提供、並びに哺乳動物細胞の透過処理、及び薬剤、例えば治療剤、造影剤、及び細胞保存剤の送達におけるそれらの使用に関する。【選択図】図9B