PROBLEM TO BE SOLVED: To provide extended release pro-liposomal, non-aqueous, pharmaceutical formulations of a hydrophobic active pharmaceutical ingredient of low water solubility but readily dissolved in alcohols, such as ropivacaine and ketoprofen.SOLUTION: The present invention provides a pharmaceutical preparation in a form of a transparent solution comprising a hydrophobic active pharmaceutical ingredient and about 40% to about 60% by weight of a natural non-synthetic phospholipid； about 30 to about 50% by weight of non-aqueous pharmaceutically acceptable carrier selected from sesame oil, cottonseed oil, safflower oil, and castor oil； and about 0.5 to about 10% by weight or about 1% to about 15% by weight of ethanol as a viscosity regulatory agent, the pharmaceutical preparation forming a liposome in vivo when exposed to body fluid. The composition is stable at normal temperature at least for 6 months, substantially lacks moisture and synthetic phospholipid, and has a viscosity less than 2500 cP.SELECTED DRAWING: None【課題】ロピバカイン、ケトプロフェン等の低水溶性で、アルコール可溶である疎水性の有効医薬成分の徐放性プロリポソーム型の非水性医薬製剤の提供。【解決手段】疎水性の有効医薬成分と約４０％～約６０重量％の天然の合成ではないリン脂質と、ゴマ油、綿実油、ベニバナ油、ヒマシ油から選択される約３０～約５０重量％の薬学上許容可能な非水性キャリアと、粘度調節剤としての約０．５～約１０重量％若しくは約１％～約１５重量％のエタノールを含む透明な溶液の形態であり、体液にさらされると生体内でリポソームを形成する医薬製剤。常温で少なくとも６ヶ月安定で、水分及び合成リン脂質を実質に欠いており、粘度が２５００ｃＰ未満である、組成物。【選択図】なし
