INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
DIMARCHI, RICHARD D.,迪玛奇 理查D,迪瑪奇 理查D
申请号：
TW102121606
公开号：
TW201402598A
申请日:
2013.06.18
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the glucagon analog of the present disclosures exhibit an EC50 at the GIP receptor which is within the nanomolar or picomolar range.本文提供展現針對GIP受體之有效活性的胰高血糖素類似物,且因而預期用於治療糖尿病及肥胖症。在例示性實施例中,本發明之胰高血糖素類似物展現之針對GIP受體之EC50在奈莫耳濃度或皮莫耳濃度範圍內。
