William A. Garland;Roger A. Sabbadini;Glenn L. Stoller
发明人:
Roger A. Sabbadini,William A. Garland,Glenn L. Stoller
申请号：
US12446723
公开号：
US08444970B2
申请日:
2007.10.26
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to compositions and methods for prevention and treatment of diseases and conditions, particularly ocular diseases and conditions, characterized by aberrant fibrogenesis or scarring, inflammation, and/or aberrant neovascularization or angiogenesis. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against the bioactive lipid, sphingosine-1-phosphate, and its variants, which moieties are capable of decreasing the effective concentration of bioactive lipid being targeted. In one embodiment, the immune-derived moiety is a humanized monoclonal antibody that is reactive against sphingosine-1-phosphate.
