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Compositions and methods for treating sphingosine-1-phosphate (S1P) related ocular diseases and conditions
专利权人:
William A. Garland;Roger A. Sabbadini;Glenn L. Stoller
发明人:
Roger A. Sabbadini,William A. Garland,Glenn L. Stoller
申请号:
US11925173
公开号:
US08614103B2
申请日:
2007.10.26
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to compositions and methods for prevention and treatment of diseases and conditions, particularly ocular diseases and conditions, characterized by aberrant fibrogenesis or scarring, inflammation, and/or aberrant neovascularization or angiogenesis. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against the bioactive lipid, sphingosine-1-phosphate, and its variants, which moieties are capable of decreasing the effective concentration of bioactive lipid being targeted. In one embodiment, the immune-derived moiety is a humanized monoclonal antibody that is reactive against sphingosine-1-phosphate.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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