2 FLUORINE-4 SUBSTITUTED-NUCLEOSIDE ANALOGUES, PREPARATION METHODS AND USES THEREOF

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专利权人:

发明人:

CHANG JUNBIAO

申请号：

IN909/DELNP/2010

公开号：

IN2010DN00909A

申请日:

2010.02.10

申请国别(地区):

IN

年份:

2013

代理人:

摘要：

The present invention provides 2"-fluorine-4"-substituted-nucleoside analogues or their pro-drugs or 5"-phosphate esters (including the pro-drugs of the 5"-phosphate esters), preparation methods and uses thereof. The compounds have the general formula as follows: (Formula Removed) wherein: R = CH3, CN, N3. C=CH R - H, F X = F,OH,NHs Y = H,CH3,F,OH,NH2 The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.

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