2-FLUORO-4-SUBSTITUTED NUCLEOSIDES, THE PREPARATION AND USE

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专利权人:

发明人:

申请号：

EP08772992.7

公开号：

EP2177527B1

申请日:

2008.06.27

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The present invention provides 2-fluorine-4-substituted-nucleoside analogues or their pro-drugs or 5-phosphate esters (including the pro-drugs of the 5-phosphate esters), preparation methods and uses thereof. The compounds have the general formula as follows:wherein:R = CH3, CH, N3, C≡CHR = H, FX = F, OH, NH2Y = H, CH3, F, OH, NH2The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.

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