INDANONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF THE VIRAL DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;카톨리에케 유니버시타이트 로이벤 케이.유. 로이벤 알 앤 디;KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D;한국화학연구원
发明人:
JUNG, YOUNG SIK,정영식,LEE, CHONG KGO,이종교,KIM, HAE SOO,김해수,JEONG, HEE CHUN,정희춘,KIM, PIL HO,김필호,HAN, SOO BONG,한수봉,SHIN, JIN SOO,신진수,JOHAN NEYTS,렛츠 요한,HENDRIK JAN THIBAUT,티바웃 핸드릭
申请号：
KR1020120065022
公开号：
KR1020120139605A
申请日:
2012.06.18
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A novel indanone derivative, a method for preparing the same, and a pharmaceutical composition containing the same are provided to ensure low cytotoxicity and to ensure excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus, and rhino virus. CONSTITUTION: An indanone derivative is denoted by chemical formula 1. A method for preparing the indanone derivative comprises acylation or alkylation of a compound of chemical formula 1 in a base and a solvent to prepare a compound of chemical formula 1a. A method for preparing the indanone derivative comprises: a step of reacting the compound of chemical formula 1 with thionyl chloride or oxalic chloride under the presence of the base and solvent； a step of reacting the resultant with ammonium to prepare a compound of chemical formula 2； and a step of acylation or alkylation of the compound of chemical formula 2 under the presence of the base and solvent to prepare a compound of chemical formula 1b. A pharmaceutical composition for preventing or treating viral diseases contains the indanone derivative of chemical formula 1, pharmaceutically acceptable salt thereof or optical isomer thereof as an active ingredient. [Reference numerals] (AA,BB) Step 1； (CC) Step 2본 발명은 신규한 인다논 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 인다논 유도체는 세포독성이 낮을 뿐만 아니라, 콕싸키바이러스, 엔테로바이러스, 에코바이러스, 폴리오바이러스, 라이노바이러스 등과 같은 피코르나바이러스에 대해 매우 우수한 항바이러스 활성을 가지므로, 소아마비, 마비, 급성출혈성 결막염, 바이러스성 수막염, 수족구병, 수포병, A형 간염, 근육염, 심근염, 췌장염, 당뇨, 유행성 근육통, 뇌염, 감기, 포진성 구협염, 구제역, 천식, 만성 폐쇄성 폐질환, 폐렴, 축농증 또는 중이염 등의 바이러스성 질환의 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.
