VAN VLIJMEN, HERMAN,LUGOVSKOY, ALEXEY ALEXANDROVIC,HANF, KARL J. M.
申请号:
EP11182599
公开号:
EP2399936A3
申请日:
2005.07.26
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention provides peptides, and fragments thereof, and antibodies, or fragments thereof comprising the same, wherein the peptide comprises at least one amino acid substitution compared to wild type 5c8 antibody. The present invention also provides compositions and methods of treating CD154-related diseases or disorders in a subject.