Stable, dried rotavirus vaccine, compositions and process for preparation thereof

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专利权人:

Sambhaji S. Pisal;Rajeev M. Dhere;Jagdish K. Zade

发明人:

Rajeev M. Dhere,Sambhaji S. Pisal,Jagdish K. Zade

申请号：

US13056557

公开号：

US08795686B2

申请日:

2009.11.06

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention provides novel lyophilized rotavirus vaccine formulations and methods of their preparation. The formulations include vaccine stabilizers, resulting in a vaccine formulation with enhanced stability and minimal loss of potency. The rotavirus vaccine formulations comprise an advantageous ratio of a disaccharide (such as sucrose) to an amino acid (such as glycine). The lyophilization results in a virus formulation with 100% virus preservation and residual moisture from about 0.8% to 1.4%.

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