YSEBAERT, NINA,GOEYVAERTS, NELE ISA E.,ROYMANS, DIRK ANDRE E.,KOUL, ANIL
申请号：
CA3006488
公开号：
CA3006488A1
申请日:
2017.02.02
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention is directed to the combination of the RSV inhibiting Compound A, i.e. 3-({5-chloro-1 -[3-(methylsulfonyl)propyl]-1 H-indol-2-yl}methyl)-1 -(2,2,2-trifluoroethyl) 1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, and one or more RSV inhibiting Compound B selected from from ribavirin, GS-5806, MDT-637, BTA-9881, BMS-433771, YM-543403, A-60444, TMC-353121, RFI-641, CL-387626, MBX-300, AZ-27, MEDI8897, CR9501, palivizumab, 3-({5-chloro-1 -[3-(methylsulfonyl)propyl]-1 H-benzimidazol-2-yl}methyl)-1 cyclopropyl-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, 3-[[7-chloro-3-(2 ethylsulfonylethyl)imidazo[1,2-a]pyridin-2-yl]methyl]-1 -cyclopropyl-imidazo[4,5-c]pyridin-2 one, N-(2-fluoro-6-methylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2 yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide, and 4-amino-8-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-6,6-dimethyl-2-(4-methyl 3-nitrophenyl)-3H-imidazo[4,5-h]isoquinoline-7,9(6H,8H)-dione, for treating or ameliorating RSV infection. The invention further relates to the combination product of Compound A and one or more Compound B, a pharmaceutical product comprising Compound A and one or more Compound B, the use of the combination of Compound A and one or more of Compound B - or the pharmaceutical product comprising CompoundA and one or more Compound B - for the treatment of RSV infection, and a method of treating or ameliorating RSV infection in a subject in need thereof comprising administering the combination of Compound A and one or more Compound B in an effective amount to said subject.
