A data acquisition system and a method of operating the data acquisition system are disclosed. A zero crossing detector generates a mains cycle start signal in accordance with a power line frequency of a mains power source. An analog-to-digital converter samples a signal provided by a test probe and generates data samples at a sampling rate. A noise replica generator generates noise replicas from the data samples at a replica generation rate, and noise estimates from the noise replicas at the sampling rate, wherein the noise replica generation rate is less than the sampling frequency. A noise removal module removes each noise estimate from a corresponding data sample.
