Goggles with a ventilation structure have a frame, a lens, and a strap. The frame has multiple ventilation portions formed on an inner peripheral surface of the frame. The lens is mounted on the frame and has multiple through holes disposed along a peripheral edge of the lens and respectively communicating with the ventilation portions. The strap has two ends respectively connected to two opposite sides of the frame. Air outside the goggles can ventilate a space defined between the lens and a face of a wearer via the ventilation portions and the through holes, so as to dissipate heat accumulated in the space and to prevent the lens from fogging. Formation of the ventilation portions and the through holes does not require expanding a shape of the frame of the goggles. Thus, the goggles have compact volume and light weight and are comfortable for wearing.