LIN, SHU YI,林淑宜,林淑宜,LO, LEU WEI,罗履维,羅履維,YANG, CHUNG SHI,杨重熙,楊重熙
申请号：
TW098124701
公开号：
TWI392869B
申请日:
2009.07.22
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
A quantum dot (QD) conjugate comprises a QD and a ligand conjugated with the QD, in which the ligand has at least one thiol and at least one other functional group. The QD conjugate may further comprise a bioactive agent covalently coupled to the ligand to form a bioactive agent-tagged QD conjugate. A method for preparing a QD conjugate comprises the steps of: (1) providing a solution comprising a QD encapsulated within a dendrimer (2) adding into the solution a ligand and (3) allowing an exchange between the ligand and the dendrimer for the QD to obtain a ligand-QD conjugate, in which the ligand is covalently conjugated to the surface of the QD. The method may further comprise the step of coupling the ligand-QD conjugate to a bioactive agent to obtain a bioactive agent-tagged ligand-QD conjugate.本發明係關於功能化量子點,量子點複合物(QD conjugate)包括量子點及一個與量子點結合的配位體,該配位體至少應含一硫醇分子和一其他官能基。量子點複合物亦包含一生物活性劑與配位體共價結合,形成一個被生物活性劑標記之量子點複合物。量子點複合物之製備步驟包含:(1)提供一內含量子點的樹狀聚合物之溶液;(2)在該溶液中加入配位體;(3)配位體和含量子點之樹狀聚合物進行表面分子置換,以取得配位體-量子點化合物,該配位體共價結合於量子點表面。合成方法亦包括配位體-量子點化合物與生物活性劑之結合,以獲取被生物活性劑標記之配位體-量子點化合物。102‧‧‧聚乙二胺聚合物104‧‧‧金量子點106‧‧‧11-巰基十一酸108‧‧‧生物分子
