An infusion planning system providing clinical decision support for dynamic patient treatment scheduling. The infusion planning system includes a graphical user interface and a rescheduling assistance engine. The graphical user interface presents a time schedule display graphically representing a plurality of patient treatments over time including at least one infusion delivery profile graphic associated with an ordered infusion. The rescheduling assistance engine includes a user interface display providing a plurality of selectable schedule updates each comprising a set of recommended changes to the patient treatments in compliance with rules governing the patient treatment. The rescheduling assistance engine also provides a selectable graphical visual preview of each of the selectable schedule updates in some embodiments.