ILGA KRIMMELBEIN,JÜRGEN KRAUS,MIRKO ZAJA,STEFAN TASLER
申请号：
BR112017019439
公开号：
BR112017019439A2
申请日:
2016.03.14
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention relates to a compound of the general formula (ii) or salt or solvate thereof, as well as medical uses, which a1 is selected from the group consisting of n and c-r8； a2 is selected from the group consisting of n and c-r3； a3 is selected from the group consisting of n and c-r9； a4 and a5 and a6 are independently selected from the group consisting of n and c-r1； R 1 is selected from the group consisting of hydrogen, (C 1 -C 3) alkyl, halogen, (C 1 -C 3) alkoxy and (C 1 -C 3) haloalkyl； R2 is selected from the group consisting of hydrogen, halogen and (C1-C3) alkyl； R3 is selected from the group consisting of hydrogen, C1-3 alkyl) alkyl, nr4r5, (C1-3) alkyl-nr4r5e cyano, which r4 and r5 are independently selected from the group consisting of hydrogen, (c3-c5) cycloalkyl, (C 3 -C 5) heterocycloalkyl and (C 1 -C 3) alkyl or R 4 and R 5 together with attached nitrogen atom form a 5- to 7-membered heterocyclic ring optionally comprising, in addition to the above-mentioned nitrogen atom, another heteroatom group selected from the above-mentioned group. group consisting of e nr6, which r6 is selected from the group consisting of hydrogen, methyl, acetyl and formyl； y is selected from the group consisting of e and s； R 8 is selected from the group consisting of (C 1 -C 4) alkyl, (C 3 -C 5) cycloalkyl and (C 3 -C 5) heterocycloalkyl； and R 9 is selected from the group consisting of hydrogen, (C 1 -C 3) alkyl, (C 1 -C 3) alkoxy； wherein certain particular compounds are excluded, and methods for producing such compounds.a presente invenção refere-se a um composto da fórmula geral (ii) ou sal ou solvato do mesmo, bem como utilizações médicas, que a1 é selecionado do grupo que consiste n e c-r8； a2 é selecionado do grupo que consiste n e c-r3； a3 é selecionado do grupo que consiste n e c-r9； a4 e a5 e a6 são independentemente selecionados do grupo que consiste n e c-r1； r1 é selecionado do grupo que consiste hidrogênio, (c1-c3)alquila, halogênio, (c1-c3)alcóxi
