연세대학교 산학협력단;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY;SOOKMYUNG WOMEN'S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;숙명여자대학교산학협력단
发明人:
RYU, Jae-Ha,류재하,LI, Hua,이화,KANG, Seok Gu,강석구
申请号：
KRKR2019/005609
公开号：
WO2019/221453A1
申请日:
2019.05.10
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to a composition for prevention and treatment of cancer, which comprises the tussilagone compound isolated from a Tussilago farfara L. extract. In assays of tussilagone: for an effect on the viability of glioblastoma multiforme (experimental example 1)； for an effect on the proliferation of the human glioblastoma cell lines U87MG and T98G (experimental example 2)； for inhibitory potential against the production of the cell energy source ATP (experimental example 3)； for an effect on the membrane potential of intracellular mitochondria (experimental example 4)； for an effect on the formation of tumor spheres (experimental example 5)； for an effect on the three-dimensional invasion of tumor spheres (experimental example 6)； and for an effect on the protein expression of FoxM1 and MGMT (experimental example 7) according to the present invention, it was found that the sample of the present invention can overcome the problem with Temodal (temozolomide, TMZ), which is currently used as a unique therapeutic agent for brain cancer, and has a more potent anticancer activity and a FoxM1 inhibition mechanism as a critical mechanism surmounting resistance, thereby overcoming the resistance problem. Being identified not only to be used as an anticancer agent as a substituent for a conventional anticancer agent such as Temodal, but also to be administered in combination of a conventional anticancer agent, with the resultant subjugation of resistance thereto, the composition can be useful as a pharmaceutical composition for prevention and treatment of cancerous disease, a health functional food, and a health food supplement.La présente invention concerne une composition pour la prévention et le traitement du cancer, qui comprend le composé tussilagone isolé à partir d'un extrait de Tussilago farfara L. Dans des essais de tussilagone: pour un effet sur la viabilité du glioblastome multiforme (exemple expérimental 1)； pour un effet sur la prolifération
