PROBLEM TO BE SOLVED: To provide means to inhibit the discoloration of, during high-temperature storage, a liquid or semisolid external antiinflammatory composition containing loxoprofen or a salt thereof.SOLUTION: A liquid or semisolid composition containing following components (A) and (B): (A) loxoprofen or a salt thereof (B) a compound represented by formula (1) or a salt thereof, is stored in a polyolefin resin-made container, to obtain a pharmaceutical formulation. [X is a single bond or O Y is a methine group or N R1 is H, a hydroxy group or an alkyl group R2 is a substituted/unsubstituted cyclic amino group, or a substituted/unsubstituted aminoalkyl group R3 is H or a halogen atom].SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】ロキソプロフェン又はその塩を含有する液状又は半固形状の外用消炎鎮痛剤組成物の、高温保存時における変色を抑制する手段の提供。【解決手段】次の成分(A)及び(B):(A)ロキソプロフェン又はその塩;(B)式(1)で表される化合物又はその塩;を含有する液状又は半固形状の組成物が、ポリオレフィン系樹脂製容器に収容されてなる、医薬製剤。[Xは単結合又はO;Yはメチン基又はN;R1はH、水酸基又はアルキル基;R2は置換/非置換の環状アミノ基、又は置換/非置換のアミノアルキル基;R3はH又はハロゲン原子]【選択図】なし
