The present invention relates to compounds of the formula Q is selected from the group consisting of G is selected from the group consisting of alkyl, substituted alkyl, substituted or unsubstituted aryl, heterocyclo, W is O or NR15 X is O or H,H Y is selected from the group consisting of O H,OR16 OR17,OR17 NOR18 H,NOR19 H,NR20R21 H,H or CHR22 OR17 OR17 can be a cyclic ketal Z1, and Z2 are selected from the group consisting of CH2, O, NR23, S, or SO2, wherein only one of Z and Z2 is a heteroatom B1 and B2 are selected from the group consisting of OR24, or OCOR25, or O2CNR26R27 when B1 is H and Y is OH, H they can form a six-membered ring ketal or acetal D is selected from the group consisting of NR28R29, NR30COR31 or saturated heterocycle R1, R2, R3, R4, R5, R6, R7, R13, R14, R18, R19, R20, R21, R22, R26, and R27 are selected from the group H, alkyl, substituted alkyl, or aryl and when R1 and R2 are alkyl can be joined to form a cycloalkyl R3 and R4 are alkyl can be joined to form a cycloalkyl R9, R10, R16, R17, R24, R25, and R31 are selected from the group H, alkyl, or substituted alkyl R8, R11, R12, R28, R30, R32, R33, and R30 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or heterocyclo R15, R23 and R29 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, heterocyclo, R32C=O, R33SO2, hydroxy, O-alkyl or O-substituted alkyl, the pharmaceutically acceptable salts thereof and any hydrates, solvates or geometric, optical and stereoisomers thereof, with the proviso that compounds wherein W and X are both O and R1, R2, R7, are H and R3, R4, R6, are methyl and R8, is H or methyl and Z1, and Z2, are CH2 and G is 1-methyl-2-(substituted-4-thiazolyl)ethenyl and Q is as defined above are excluded.
