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Hyaluronic acid based formulations
专利权人:
Allergan Industrie; SAS
发明人:
LEBRETON, Pierre,GUETTA, Olivier
申请号:
ES11799644
公开号:
ES2637202T3
申请日:
2011.11.08
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Composition of soft tissue filler material comprising: (1) a crosslinked hyaluronic acid (HA) component comprising a crosslinked mixture of (i) a first low molecular weight HA material having an average molecular weight of between 0 , 20 MDa and 0.99 MDa, and (ii) a second high molecular weight HA material having an average molecular weight between 1.0 MDa and 4.0 MDa; wherein: the average molecular weight of the second high molecular weight HA material is at least twice that of the first low molecular weight HA material; HA materials are hyaluronic acid or one or more salts thereof; the crosslinked HA component has a concentration of HA material between 15.0 mg / g and 20.0 mg / g; the crosslinked mixture contains more than 50% w / w of the first low molecular weight HA material; and crosslinking is achieved through the use of a crosslinking agent; and (2) a crosslinked HA solution comprising between 27 mg / g and 33 mg / g of uncrosslinked HA or a salt thereof having an average molecular weight between 1.0 MDa and 4.0 MDa, and which is present in the composition in an amount of at least 0.5% w / w and less than 5.0% w / w; where each average molecular weight (PM) is calculated using the following equation: PM>; = [η / (9.78 x 10-5)] 1.45 in which η is the intrinsic viscosity in m3 / kg of the material of HA, as measured using the method defined in the European Pharmacopoeia (Farm. Eur.), monograph No. 1472, 01/2009Composición de material de relleno de tejidos blandos que comprende: (1) un componente de ácido hialurónico (HA) reticulado que comprende una mezcla reticulada de (i) un primer material de HA de bajo peso molecular que tiene un peso molecular promedio de entre 0,20 MDa y 0,99 MDa, y (ii) un segundo material de HA de alto peso molecular que tiene un peso molecular promedio de entre 1,0 MDa y 4,0 MDa; en la que: el peso molecular promedio del segundo material de HA de alto peso molecular es al menos dos veces el del primer material de HA de bajo peso mol
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