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Hyaluronic acid based formulations
专利权人:
ALLERGAN INDUSTRIE SAS
发明人:
Lebreton Pierre,Guetta Olivier
申请号:
NZ70824711
公开号:
NZ708247A
申请日:
2011.11.08
申请国别(地区):
NZ
年份:
2017
代理人:
摘要:
Discloses a soft tissue filler composition comprising: (1) a crosslinked hyaluronic acid (HA) component comprising a crosslinked mixture of (i) a first, low molecular weight HA material having a weight average molecular weight of between 0.20 about MDa and about 0.99 MDa and (ii) a second high molecular weight HA material having a weight average molecular weight of between about 1.0 MDa and about 4.0 MDa; wherein the weight average molecular weight of the second, high molecular weight HA material is at least twice that of the first, low molecular weight HA material; wherein the HA materials are hyaluronic acid or one or more salts thereof; wherein the crosslinked HA component has a HA concentration of between about 15.0 mg/g and about 20.0 mg/g; and wherein the crosslinking is achieved by use of a crosslinking agent; and (2) an uncrosslinked HA component which is HA or a salt thereof, and which has a weight average molecular weight of at least about 1.0 MDa and is present in the composition in an amount of less than about 5.0% w/w.
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