LAUER PETER M,HANSON WILLIAM G,SKOBLE JUSTIN,LEONG MEREDITH LAI LING,FASSO MARCELLA,BROCKSTEDT DIRK,DUBENSKY THOMAS W
申请号：
IN607/MUMNP/2015
公开号：
IN2015MN00607A
申请日:
2015.03.19
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention provides nucleic acids expression systems and vaccine strains which provide efficient expression and secretion of antigens of interest into the cytosol of host cells and elicit effective CD4 and CD8 T cell responses by functionally linking Listerial or other bacterial signal peptides/secretion chaperones as N terminal fusion partners in translational reading frame with selected recombinant encoded protein antigens. These N terminal fusion partners are deleted (either by actual deletion by mutation or by a combination of these approaches) for any PEST sequences native to the sequence and/or for certain hydrophobic residues.
