您的位置: 首页 > 农业专利 > 详情页

SIGNAL PEPTIDE FUSION PARTNERS FACILITATING LISTERIAL EXPRESSION OF ANTIGENIC SEQUENCES AND METHODS OF PREPARATION AND USE THEREOF
专利权人:
发明人:
LAUER PETER M,HANSON WILLIAM G,SKOBLE JUSTIN,LEONG MEREDITH LAI LING,FASSO MARCELLA,BROCKSTEDT DIRK,DUBENSKY THOMAS W
申请号:
IN607/MUMNP/2015
公开号:
IN2015MN00607A
申请日:
2015.03.19
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The present invention provides nucleic acids expression systems and vaccine strains which provide efficient expression and secretion of antigens of interest into the cytosol of host cells and elicit effective CD4 and CD8 T cell responses by functionally linking Listerial or other bacterial signal peptides/secretion chaperones as N terminal fusion partners in translational reading frame with selected recombinant encoded protein antigens. These N terminal fusion partners are deleted (either by actual deletion by mutation or by a combination of these approaches) for any PEST sequences native to the sequence and/or for certain hydrophobic residues.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充