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Fused aminodihydrothiazine derivatives
专利权人:
Yuichi Suzuki
发明人:
Yuichi Suzuki,Takafumi Motoki,Toshihiko Kaneko,Mamoru Takaishi,Tasuku Ishida,Kunitoshi Takeda,Yoichi Kita,Noboru Yamamoto,Afzal Khan,Paschalis Dimopoulos
申请号:
US12355154
公开号:
US08158620B2
申请日:
2009.01.16
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A compound represented by the general formula:or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
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