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Fused aminodihydrothiazine derivative
专利权人:
Mamoru Takaishi;Tasuku Ishida;Yuichi Suzuki;Takafumi Motoki;Yoichi Kita;Kunitoshi Takeda
发明人:
Takafumi Motoki,Kunitoshi Takeda,Yoichi Kita,Mamoru Takaishi,Yuichi Suzuki,Tasuku Ishida
申请号:
US12568151
公开号:
US08198269B2
申请日:
2009.09.28
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A compound represented by the general formula:wherein Ring A is a C6-14 aryl group or the like, L is —NRLCO— or the like (wherein RL is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a C1-3 alkylene group or the like, Z is an oxygen atom or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, or a pharmaceutically acceptable salt thereof, or a solvate thereof, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
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